InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbtb46

Summary

InnateDB Protein

IDBP-214109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbtb46

Protein Name

zinc finger and BTB domain containing 46

Synonyms

2610019F01Rik; 4933406L05Rik; Btbd4; BZEL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029106

InnateDB Gene

IDBG-214107 (Zbtb46)

Protein Structure

UniProt Annotation

Function

Function as a transcriptional repressor for PRDM1. {ECO:0000269PubMed:22370726}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030853	negative regulation of granulocyte differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:2001199	negative regulation of dendritic cell differentiation
GO:2001200	positive regulation of dendritic cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1919397

InterPro

IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
IPR021777 Protein of unknown function DUF3342

PFAM

PF00096
PF00651
PF11822

PRINTS

PIRSF

SMART

SM00225
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BID6