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InnateDB Protein
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IDBP-253225.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tprkb
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Protein Name
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Tp53rk binding protein
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Synonyms
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0610033G21Rik; 1810034M08Rik; Cgi-121; DRWMS1; mDRWMS1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109381
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InnateDB Gene
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IDBG-164173 (Tprkb)
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Protein Structure
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| Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
9 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0019901
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protein kinase binding
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1917036
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| InterPro |
IPR013926
CGI121/TPRKB
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| PFAM |
PF08617
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8QZZ7
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| PhosphoSite |
PhosphoSite-Q8QZZ7
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| TrEMBL |
D3Z5E8
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| UniProt Splice Variant |
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| Entrez Gene |
69786
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| UniGene |
Mm.218434
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Tprkb
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| OMIM |
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| CCDS |
CCDS20305
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| HPRD |
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| IMGT |
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| EMBL |
AC158679
BC024858
BC027162
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| GenPept |
AAH24858
AAH27162
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Version 5.4