InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PES1

Summary

InnateDB Protein

IDBP-4256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PES1

Protein Name

pescadillo homolog 1, containing BRCT domain (zebrafish)

Synonyms

PES;

Species

Homo sapiens

Ensembl Protein

ENSP00000346725

InnateDB Gene

IDBG-4252 (PES1)

Protein Structure

UniProt Annotation

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03028, ECO:0000269PubMed:16738141, ECO:0000269PubMed:17189298, ECO:0000269PubMed:17353269}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255HAMAP-Rule:MF_03028}.

Disease Associations

Tissue Specificity

Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0007000	nucleolus organization
GO:0008283	cell proliferation
GO:0033365	protein localization to organelle
GO:0042254	ribosome biogenesis
GO:0042273	ribosomal large subunit biogenesis
GO:0051726	regulation of cell cycle

Cellular Component

GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030687	preribosome, large subunit precursor
GO:0070545	PeBoW complex