Version 5.4
Homo sapiens Protein: TPRKB
Summary
InnateDB Protein IDBP-56605.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPRKB
Protein Name TP53RK binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000325398
InnateDB Gene IDBG-56603 (TPRKB)
Protein Structure
UniProt Annotation
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12659830}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR013926 CGI121/TPRKB
PFAM PF08617
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3C4
PhosphoSite PhosphoSite-Q9Y3C4
TrEMBL
UniProt Splice Variant
Entrez Gene 51002
UniGene Hs.157401
RefSeq XP_005264400
HUGO HGNC:24259
OMIM 608680
CCDS
HPRD
IMGT
EMBL AF060921 AF151879 AY157986 AY157987 BC029492 CH471053
GenPept AAD34116 AAG43133 AAH29492 AAN76356 AAN76357 EAW99720 EAW99722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca