InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C5AR1

Summary

InnateDB Protein

IDBP-59447.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C5AR1

Protein Name

complement component 5a receptor 1

Synonyms

C5A; C5AR; C5R1; CD88;

Species

Homo sapiens

Ensembl Protein

ENSP00000347197

InnateDB Gene

IDBG-59445 (C5AR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001856	complement component C5a binding
GO:0004878	complement component C5a receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004944	C5a anaphylatoxin receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0002430	complement receptor mediated signaling pathway
GO:0006915	apoptotic process
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007606	sensory perception of chemical stimulus
GO:0021534	cell proliferation in hindbrain
GO:0030593	neutrophil chemotaxis
GO:0031100	organ regeneration
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0038178	complement component C5a signaling pathway
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050830	defense response to Gram-positive bacterium
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000496 Bradykinin receptor family
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
IPR002234 Anaphylatoxin chemotactic receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00425
PR00426
PR01104

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21730