InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH6

Summary

InnateDB Protein

IDBP-596332.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH6

Protein Name

mutS homolog 6 (E. coli)

Synonyms

GTBP; GTMBP; HNPCC5; HSAP; p160;

Species

Homo sapiens

Ensembl Protein

ENSP00000438580

InnateDB Gene

IDBG-51044 (MSH6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	85 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000400	four-way junction DNA binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding
GO:0032137	guanine/thymine mispair binding
GO:0032142	single guanine insertion binding
GO:0032143	single thymine insertion binding
GO:0032357	oxidized purine DNA binding
GO:0032405	MutLalpha complex binding
GO:0035064	methylated histone binding
GO:0043531	ADP binding

Biological Process

GO:0000710	meiotic mismatch repair
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0007131	reciprocal meiotic recombination
GO:0008340	determination of adult lifespan
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0045190	isotype switching
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0000228	nuclear chromosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0032301	MutSalpha complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR007861 DNA mismatch repair protein MutS, clamp
IPR016151 DNA mismatch repair protein MutS, N-terminal
IPR017261 DNA mismatch repair protein Msh6
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF01624
PF05192
PF05188
PF05190

PRINTS

PIRSF

PIRSF037677

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt