InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1A

Summary

InnateDB Protein

IDBP-66484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1A

Protein Name

interleukin 1, alpha

Synonyms

IL-1A; IL1; IL1-ALPHA; IL1F1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263339

InnateDB Gene

IDBG-66482 (IL1A)

Protein Structure

UniProt Annotation

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subcellular Localization

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019221	cytokine-mediated signaling pathway
GO:0034605	cellular response to heat
GO:0035234	ectopic germ cell programmed cell death
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046688	response to copper ion
GO:0050715	positive regulation of cytokine secretion
GO:0051781	positive regulation of cell division
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR003295 Interleukin-1 alpha
IPR003502 Interleukin-1 propeptide
IPR008996 Cytokine, IL-1-like

PFAM

PF00340
PF02394

PRINTS

PR00264
PR01357
PR01358

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01583