InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH6

Summary

InnateDB Protein

IDBP-808381.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH6

Protein Name

mutS homolog 6

Synonyms

GTBP; GTMBP; HNPCC5; HSAP; p160;

Species

Homo sapiens

Ensembl Protein

ENSP00000477844

InnateDB Gene

IDBG-51044 (MSH6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	85 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0030983	mismatched DNA binding

Biological Process

GO:0006298

mismatch repair

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR007861 DNA mismatch repair protein MutS, clamp
IPR016151 DNA mismatch repair protein MutS, N-terminal
IPR017261 DNA mismatch repair protein Msh6
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF01624
PF05192
PF05188
PF05190

PRINTS

PIRSF

PIRSF037677

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt