InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL1A

Summary

InnateDB Gene

IDBG-634609.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1A

Gene Name

Interleukin-1 alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010349

Encoded Proteins

IDBP-686382

Interleukin-1 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25463072

[Homo sapiens] Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.

PMID 25474109

[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.

PMID 25964352

[Homo sapiens] CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release

PMID 26439902

[Homo sapiens] IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

PMID 24022484

[Mus musculus] Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.

PMID 24651866

[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 26536497

[Mus musculus] NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.

PMID 26439902

[Mus musculus] Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115008:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46349422-46360402

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013665

ENSBTAP00000013665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019221	cytokine-mediated signaling pathway
GO:0034605	cellular response to heat
GO:0035234	ectopic germ cell programmed cell death
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046688	response to copper ion
GO:0050715	positive regulation of cytokine secretion
GO:0051781	positive regulation of cell division
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand