InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il1a

Summary

InnateDB Gene

IDBG-205910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1a

Gene Name

interleukin 1 alpha

Synonyms

Il-1a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027399

Encoded Proteins

IDBP-205912

interleukin 1 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24022484

Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.

PMID 24651866

In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 26536497

NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.

PMID 26439902

Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

InnateDB Annotation from Orthologs

Summary

PMID 25463072

[Homo sapiens] Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.

PMID 25474109

[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.

PMID 25964352

[Homo sapiens] CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release

PMID 26439902

[Homo sapiens] IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115008:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:129299610-129309972

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028882

ENSMUSP00000028882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019221	cytokine-mediated signaling pathway
GO:0034605	cellular response to heat
GO:0035234	ectopic germ cell programmed cell death
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046688	response to copper ion
GO:0050715	positive regulation of cytokine secretion
GO:0051781	positive regulation of cell division
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand