InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1a

Summary

InnateDB Protein

IDBP-205912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1a

Protein Name

interleukin 1 alpha

Synonyms

Il-1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028882

InnateDB Gene

IDBG-205910 (Il1a)

Protein Structure

UniProt Annotation

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subcellular Localization

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019221	cytokine-mediated signaling pathway
GO:0034605	cellular response to heat
GO:0035234	ectopic germ cell programmed cell death
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046688	response to copper ion
GO:0050715	positive regulation of cytokine secretion
GO:0051781	positive regulation of cell division
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:96542

InterPro

IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR003295 Interleukin-1 alpha
IPR003502 Interleukin-1 propeptide
IPR008996 Cytokine, IL-1-like

PFAM

PF00340
PF02394

PRINTS

PR00264
PR01357
PR01358

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01582